Clomiphene as well as all of the triphenylethylene compounds under the SERM family (tamoxifen, clomiphene and toremifene) also exhibit estrogen agonistic effects. Clomiphene, being a SERM, does not reduce circulating estradiol levels in the blood, but instead serves to occupy the receptor sites so that estrogen itself cannot bind to these receptors due to clomiphene’s stronger binding strength to them. So, clomiphene binds to estrogen receptors on cells blocking them to estrogen in the blood. However, it should be noted that clomiphene actually operates at a much poorer efficiency compared to tamoxifen in regards to its estrogen antagonistic activity in breast tissue.
The average starting clomiphene dosage should be at about 150mg per day, and should hold at this level for 1-2 weeks. From there it should decrease to 100mg for another 1-2 weeks, with the final clomiphene dosage falling to 25-50mg per day for the final week of PCT. Exact dosages are individual-dependent and shall be determined based on blood work results.